Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties.
نویسندگان
چکیده
We report the synthesis and biophysical characterization of a novel class of zwitterionic lipids (ZL) with head groups containing a 3° or 4° amine and carboxylate. ZL form stable liposomes that exhibit head group dependent, pH-responsive biophysical characteristics. These lipids may be suitable components for drug delivery applications due to their ease of synthesis and unique pH-dependent properties.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 45 شماره
صفحات -
تاریخ انتشار 2012